BDBM50052524 (S)-N-((S)-1-{[(S)-1-({[(S)-1-((S)-1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-3-(3-carboxy-propionylamino)-succinamic acid::CHEMBL106124::senktide
SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(N)=O
InChI Key InChIKey=HMHYXLVEFVGOPM-QKUYTOGTSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50052524
Affinity DataKi: 3.20nMAssay Description:Displacement of [125I][MePhe7]NKB from human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Effective concentration to activate Tachykinin receptor 3 in rat portal vein (RPV)More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Displacement of [125I]His3, MePhe7 from human NK3R expressed in CHO cell membranes by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effectMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Agonist activity at rat NK3RMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Activity at human NK3 receptor expressed in CHO cells assessed as increase in inositol phosphate generationMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Displacement of [125I][MePhe]-NKB from human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125I]Bolton-Hunter substance PMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against cloned human Tachykinin receptor 3 in CHO cells labeled with [125I][MePhe7]-NKBMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against Tachykinin receptor 3 in guinea pig cortical membranes labeled with [125I]-[MePhe7]More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Binding affinity towards human Tachykinin receptor 3 stably expressed in CHO cells using [125I][MePhe7]-NKB as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+5nMAssay Description:Effective concentration to activate Tachykinin receptor 2 in rat vas deferens (RVD)More data for this Ligand-Target Pair
Affinity DataEC50: 7nMAssay Description:Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against Tachykinin receptor 3 in guinea pig cortical membranes labeled with [125I]-[MePhe7]More data for this Ligand-Target Pair
Affinity DataEC50: 3.50E+4nMAssay Description:Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)More data for this Ligand-Target Pair