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BDBM50052551 2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid::CHEMBL107768

InChI string: InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)

SMILES: Cc1o[nH]c(=O)c1CCC(N)C(O)=O

InChI Key: InChIKey=NZDIZJGEDFARSV-UHFFFAOYSA-N

Data: 8 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50052551   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50052551
PNG
(2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyr...)
Show SMILES Cc1o[nH]c(=O)c1CCC(N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)
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PubMed
n/an/an/an/a>3.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 4


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052551
PNG
(2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyr...)
Show SMILES Cc1o[nH]c(=O)c1CCC(N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)
PDB

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PubMed
n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 2


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
metabotropic glutamate 1/2


(RAT)
BDBM50052551
PNG
(2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyr...)
Show SMILES Cc1o[nH]c(=O)c1CCC(N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)
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PubMed
n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 1


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50052551
PNG
(2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyr...)
Show SMILES Cc1o[nH]c(=O)c1CCC(N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)
Reactome pathway
KEGG

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PubMed
n/an/an/an/a 8.20E+4n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonistic activity at mGlu6 receptor expressed in CHO cells


J Med Chem 39: 3188-94 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052551
PNG
(2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyr...)
Show SMILES Cc1o[nH]c(=O)c1CCC(N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonistic activity at mGlu1-alpha receptor expressed in CHO cells


J Med Chem 39: 3188-94 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052551
PNG
(2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyr...)
Show SMILES Cc1o[nH]c(=O)c1CCC(N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)
PDB

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PubMed
n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonistic activity at mGlu2 receptor expressed in CHO cells


J Med Chem 39: 3188-94 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052551
PNG
(2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyr...)
Show SMILES Cc1o[nH]c(=O)c1CCC(N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)
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n/an/an/an/a>3.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonistic activity at mGlu4a receptor expressed in CHO cells


J Med Chem 39: 3188-94 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50052551
PNG
(2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyr...)
Show SMILES Cc1o[nH]c(=O)c1CCC(N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)
UniProtKB/SwissProt

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PC cid
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Article
PubMed
n/an/an/an/a 8.20E+4n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 6


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair