BDBM50055931 CHEMBL3321933::US9884814, Compound 272

SMILES COc1ccc(CC(=O)NC(=N)N[C@H](CC2CCCCC2)C(=O)NCc2ccc(cc2)-c2nnn[nH]2)cc1OC

InChI Key InChIKey=AEWGFSGAPHPPHI-JOCHJYFZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50055931   

TargetCathepsin D(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50055931(CHEMBL3321933 | US9884814, Compound 272)
Affinity DataIC50:  44nMAssay Description:Inhibition of human liver cathepsin D using MCA-labeled GKPILFFRLK(Dnp)-D-R-NH2 peptide by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50055931(CHEMBL3321933 | US9884814, Compound 272)
Affinity DataIC50:  44nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin D(Bos taurus)
Merck

Curated by ChEMBL
LigandPNGBDBM50055931(CHEMBL3321933 | US9884814, Compound 272)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of cathepsin D in bovine cartilage explants assessed as reduction in sulphated GAGs level after 3 days by spectrophotometric 1,9-dimethylm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed