BDBM50058204 (S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid::CHEMBL48866::RPR-113829

SMILES CSCC[C@H](NC(=O)c1cccc2cc(NC[C@@H](N)CS)ccc12)C(O)=O

InChI Key InChIKey=YUXOGMIOPNYIQR-DYVFJYSZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50058204   

TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50058204((S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Affinity DataIC50:  17.5nMAssay Description:Inhibition of [3H]-FPP incorporation into human Ki-Ras by farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50058204((S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of FTase (unknown origin) assessed as reduction in transfer of [3H]FPP to Ha-RasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50058204((S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Affinity DataIC50:  17nMAssay Description:Inhibition of FTase (unknown origin) assessed as reduction in transfer of [3H]FPP to Ki-RasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50058204((S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed