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BDBM50058590 CHEMBL293743::Fenleuton::N-{3-[3-(4-fluorophenoxy)phenyl]-1-methylprop-2-ynyl}-N-hydroxyurea

SMILES: CC(C#Cc1cccc(Oc2ccc(F)cc2)c1)N(O)C(N)=O

InChI Key: InChIKey=MWXPQCKCKPYBDR-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50058590   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50058590
PNG
(CHEMBL293743 | Fenleuton | N-{3-[3-(4-fluorophenox...)
Show SMILES CC(C#Cc1cccc(Oc2ccc(F)cc2)c1)N(O)C(N)=O
Show InChI InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21)
PDB
MMDB

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Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).


J Med Chem 40: 1955-68 (1997)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50058590
PNG
(CHEMBL293743 | Fenleuton | N-{3-[3-(4-fluorophenox...)
Show SMILES CC(C#Cc1cccc(Oc2ccc(F)cc2)c1)N(O)C(N)=O
Show InChI InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production


J Med Chem 40: 1955-68 (1997)

More data for this
Ligand-Target Pair