BDBM50059084 CHEMBL3393171::US10308663, Thienopyridone (5)
SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
InChI Key InChIKey=FBVOPOZVLBHOHR-UHFFFAOYSA-N
Data 13 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50059084
TargetProtein tyrosine phosphatase type IVA 1(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 173nMAssay Description:Inhibition of full length human fusion His6 tagged PRL1 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 substrate by imm...More data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 2(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 277nMAssay Description:Inhibition of human PRL2 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 substrate by immobilized metal ion affinity-bas...More data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 128nMAssay Description:Inhibition of full length human fusion His6 tagged PRL3 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 substrate by imm...More data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylationMore data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 2(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 1.04E+5nMAssay Description:Inhibition of PRL2 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylationMore data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 1(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of PRL1 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylationMore data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 2(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of human His6-tagged PRL-2 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 peptide as substrate by IMAP-FP as...More data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 2(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant human His-6-tagged PTP4A2 expressed in Escherichia coli assessed as increase in polarization using TAMRAThr-Ala-Asp-Ile-Tyr...More data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 1(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant human His-6-tagged PTP4A1 expressed in Escherichia coli assessed as increase in polarization using TAMRAThr-Ala-Asp-Ile-Tyr...More data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as increase in polarization using TAMRAThr-Ala-Asp-Ile-Tyr...More data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 460nMAssay Description:Inhibition of full-length human heart His6-tagged PRL-3 expressed in Escherichia coli using DiFMUP as substrate incubated for 35 mins by fluorescence...More data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 1(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of full-length human brain His6-tagged PRL-1 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 peptide as subst...More data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 132nMAssay Description:The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....More data for this Ligand-Target Pair