BDBM50060627 (S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid::(S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid::2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID::CHEMBL121915
SMILES: N[C@@H](Cn1cc(I)c(=O)[nH]c1=O)C(O)=O
InChI Key: InChIKey=AXXYLTBQIQBTES-BYPYZUCNSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Grik5 (Homo sapiens (Human)) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells | J Med Chem 40: 3645-50 (1997) Article DOI: 10.1021/jm9702387 BindingDB Entry DOI: 10.7270/Q28G8MCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate kainate (RAT) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs) Curated by ChEMBL | Assay Description Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cells | J Med Chem 51: 6614-8 (2008) Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (GluA1) (Rattus norvegicus (Rat)) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs) Curated by ChEMBL | Assay Description Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells | J Med Chem 51: 6614-8 (2008) Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, AMPA 2 (Rattus norvegicus) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs) Curated by ChEMBL | Assay Description Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cells | J Med Chem 51: 6614-8 (2008) Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GRIA1 (Homo sapiens (Human)) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 163 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cells | J Med Chem 40: 3645-50 (1997) Article DOI: 10.1021/jm9702387 BindingDB Entry DOI: 10.7270/Q28G8MCB | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GRIA2 (Homo sapiens (Human)) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 176 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cells | J Med Chem 40: 3645-50 (1997) Article DOI: 10.1021/jm9702387 BindingDB Entry DOI: 10.7270/Q28G8MCB | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic, AMPA 4 (Rattus norvegicus) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 738 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs) Curated by ChEMBL | Assay Description Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR4 expressed in Sf9 cells | J Med Chem 51: 6614-8 (2008) Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic AMPA (Homo sapiens (Human)) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 972 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 4 expressed in HEK293 cells | J Med Chem 40: 3645-50 (1997) Article DOI: 10.1021/jm9702387 BindingDB Entry DOI: 10.7270/Q28G8MCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GRIA3 (RAT) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 976 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs) Curated by ChEMBL | Assay Description Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells | J Med Chem 51: 6614-8 (2008) Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Ionotropic glutamate receptor kainate 2/5 (Rattus norvegicus) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs) Curated by ChEMBL | Assay Description Displacement of [3H]kainic acid from rat recombinant iGluR6(V,C,R) receptor expressed in Sf9 cells | J Med Chem 51: 6614-8 (2008) Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, kainate (Rattus norvegicus) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Potency on Ionotropic glutamate receptor kainate in dorsal root ganglion cells | J Med Chem 40: 3645-50 (1997) Article DOI: 10.1021/jm9702387 BindingDB Entry DOI: 10.7270/Q28G8MCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (GluA1) (Rattus norvegicus (Rat)) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.92E+4 | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Potency on Ionotropic glutamate receptor AMPA in hippocampal neurons | J Med Chem 40: 3645-50 (1997) Article DOI: 10.1021/jm9702387 BindingDB Entry DOI: 10.7270/Q28G8MCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (GluA1) (Rattus norvegicus (Rat)) | BDBM50060627![]() ((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.36E+4 | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs) Curated by ChEMBL | Assay Description Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electro... | J Med Chem 51: 6614-8 (2008) Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R | |||||||||||
More data for this Ligand-Target Pair |