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BDBM50060634 (S)-2-Amino-3-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-propionic acid::CHEMBL122656

SMILES: N[C@@H](Cn1ncc(=O)[nH]c1=O)C(O)=O

InChI Key: InChIKey=YUUMCVSQULVXBC-VKHMYHEASA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50060634   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GRIA1


(Homo sapiens (Human))
BDBM50060634
PNG
((S)-2-Amino-3-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]tri...)
Show SMILES N[C@@H](Cn1ncc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H8N4O4/c7-3(5(12)13)2-10-6(14)9-4(11)1-8-10/h1,3H,2,7H2,(H,12,13)(H,9,11,14)/t3-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
163n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50060634
PNG
((S)-2-Amino-3-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]tri...)
Show SMILES N[C@@H](Cn1ncc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H8N4O4/c7-3(5(12)13)2-10-6(14)9-4(11)1-8-10/h1,3H,2,7H2,(H,12,13)(H,9,11,14)/t3-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
189n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 4 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50060634
PNG
((S)-2-Amino-3-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]tri...)
Show SMILES N[C@@H](Cn1ncc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H8N4O4/c7-3(5(12)13)2-10-6(14)9-4(11)1-8-10/h1,3H,2,7H2,(H,12,13)(H,9,11,14)/t3-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
461n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
Grik5


(Homo sapiens (Human))
BDBM50060634
PNG
((S)-2-Amino-3-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]tri...)
Show SMILES N[C@@H](Cn1ncc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H8N4O4/c7-3(5(12)13)2-10-6(14)9-4(11)1-8-10/h1,3H,2,7H2,(H,12,13)(H,9,11,14)/t3-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.98E+3n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair