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BDBM50060679 7-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxaline::CHEMBL120216

SMILES: Fc1ccc2c(c1)nc(N1CCNCC1)c1cccn21

InChI Key: InChIKey=YFOGAJAEMHMGIZ-UHFFFAOYSA-N

Data: 6 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50060679   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50060679
PNG
(7-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1ccc2c(c1)nc(N1CCNCC1)c1cccn21
Show InChI InChI=1S/C15H15FN4/c16-11-3-4-13-12(10-11)18-15(14-2-1-7-20(13)14)19-8-5-17-6-9-19/h1-4,7,10,17H,5-6,8-9H2
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PC sid
UniChem

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Article
PubMed
n/an/a 167n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptor


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50060679
PNG
(7-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1ccc2c(c1)nc(N1CCNCC1)c1cccn21
Show InChI InChI=1S/C15H15FN4/c16-11-3-4-13-12(10-11)18-15(14-2-1-7-20(13)14)19-8-5-17-6-9-19/h1-4,7,10,17H,5-6,8-9H2
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PubMed
n/an/a 5.40n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50060679
PNG
(7-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1ccc2c(c1)nc(N1CCNCC1)c1cccn21
Show InChI InChI=1S/C15H15FN4/c16-11-3-4-13-12(10-11)18-15(14-2-1-7-20(13)14)19-8-5-17-6-9-19/h1-4,7,10,17H,5-6,8-9H2
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n/an/a 151n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of radiolabeled [3H]-8-OH-DPAT ligand binding to 5-hydroxytryptamine 1A receptor


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50060679
PNG
(7-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1ccc2c(c1)nc(N1CCNCC1)c1cccn21
Show InChI InChI=1S/C15H15FN4/c16-11-3-4-13-12(10-11)18-15(14-2-1-7-20(13)14)19-8-5-17-6-9-19/h1-4,7,10,17H,5-6,8-9H2
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PC cid
PC sid
UniChem

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PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of radiolabeled [3H]GR-113808 ligand binding to 5-hydroxytryptamine 4 receptor


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C)


(Rattus norvegicus (Rat))
BDBM50060679
PNG
(7-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1ccc2c(c1)nc(N1CCNCC1)c1cccn21
Show InChI InChI=1S/C15H15FN4/c16-11-3-4-13-12(10-11)18-15(14-2-1-7-20(13)14)19-8-5-17-6-9-19/h1-4,7,10,17H,5-6,8-9H2
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Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of radiolabeled [3H]mesulergine ligand binding to 5-hydroxytryptamine 2C receptor


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50060679
PNG
(7-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1ccc2c(c1)nc(N1CCNCC1)c1cccn21
Show InChI InChI=1S/C15H15FN4/c16-11-3-4-13-12(10-11)18-15(14-2-1-7-20(13)14)19-8-5-17-6-9-19/h1-4,7,10,17H,5-6,8-9H2
Reactome pathway
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Article
PubMed
n/an/a 489n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of radiolabeled [3H]-Ketanserin ligand binding to 5-hydroxytryptamine 2A receptor


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair