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BDBM50060684 9-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxaline::CHEMBL331304

SMILES: Fc1cccc2nc(N3CCNCC3)c3cccn3c12

InChI Key: InChIKey=WTIHQLOVALBPDM-UHFFFAOYSA-N

Data: 6 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50060684   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50060684
PNG
(9-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1cccc2nc(N3CCNCC3)c3cccn3c12
Show InChI InChI=1S/C15H15FN4/c16-11-3-1-4-12-14(11)20-8-2-5-13(20)15(18-12)19-9-6-17-7-10-19/h1-5,8,17H,6-7,9-10H2
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PubMed
n/an/a 106n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptor


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50060684
PNG
(9-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1cccc2nc(N3CCNCC3)c3cccn3c12
Show InChI InChI=1S/C15H15FN4/c16-11-3-1-4-12-14(11)20-8-2-5-13(20)15(18-12)19-9-6-17-7-10-19/h1-5,8,17H,6-7,9-10H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of radiolabeled [3H]GR-113808 ligand binding to 5-hydroxytryptamine 4 receptor


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C)


(Rattus norvegicus (Rat))
BDBM50060684
PNG
(9-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1cccc2nc(N3CCNCC3)c3cccn3c12
Show InChI InChI=1S/C15H15FN4/c16-11-3-1-4-12-14(11)20-8-2-5-13(20)15(18-12)19-9-6-17-7-10-19/h1-5,8,17H,6-7,9-10H2
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n/an/a 784n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of radiolabeled [3H]mesulergine ligand binding to 5-hydroxytryptamine 2C receptor


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50060684
PNG
(9-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1cccc2nc(N3CCNCC3)c3cccn3c12
Show InChI InChI=1S/C15H15FN4/c16-11-3-1-4-12-14(11)20-8-2-5-13(20)15(18-12)19-9-6-17-7-10-19/h1-5,8,17H,6-7,9-10H2
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n/an/a 761n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of radiolabeled [3H]-Ketanserin ligand binding to 5-hydroxytryptamine 2A receptor


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50060684
PNG
(9-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1cccc2nc(N3CCNCC3)c3cccn3c12
Show InChI InChI=1S/C15H15FN4/c16-11-3-1-4-12-14(11)20-8-2-5-13(20)15(18-12)19-9-6-17-7-10-19/h1-5,8,17H,6-7,9-10H2
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PC sid
UniChem

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Article
PubMed
n/an/a 3.90n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50060684
PNG
(9-Fluoro-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Fc1cccc2nc(N3CCNCC3)c3cccn3c12
Show InChI InChI=1S/C15H15FN4/c16-11-3-1-4-12-14(11)20-8-2-5-13(20)15(18-12)19-9-6-17-7-10-19/h1-5,8,17H,6-7,9-10H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 268n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of radiolabeled [3H]-8-OH-DPAT ligand binding to 5-hydroxytryptamine 1A receptor


J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair