BDBM50061441 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone::CHEMBL311310

SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncccc3CCc2c1

InChI Key InChIKey=QIVUVRPLLRMTDC-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50061441   

TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50061441(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against recombinant human farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50061441(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)
Affinity DataIC50:  160nMAssay Description:In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogeneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50061441(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of Farnesyltransferase from Ras-CVLS or Ras-CVLL in Cos-7 monkey kidney cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50061441(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)
Affinity DataIC50:  36nMAssay Description:In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus (rat))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50061441(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)
Affinity DataIC50: >4.60E+4nMAssay Description:Inhibition of rat Geranylgeranyl transferase (GGPT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50061441(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)
Affinity DataIC50:  3.70E+3nMAssay Description:In vitro inhibition of Ras processing in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50061441(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against recombinant human farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed