BDBM50061554 (+)-Silychristin::(2R,3R)-3,5,7-Trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-3-hydroxymethyl-2,3-dihydro-benzofuran-5-yl]-chroman-4-one::CHEMBL130493::SILYCHRISTIN

SMILES COc1cc(ccc1O)[C@@H]1Oc2c(cc(cc2O)[C@H]2Oc3cc(O)cc(O)c3C(O)C2=O)[C@H]1CO

InChI Key InChIKey=MUKQBXKBYBEXHP-FTWIWWOYSA-N

Data  4 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50061554   

TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50061554((+)-Silychristin | (2R,3R)-3,5,7-Trihydroxy-2-[(2R...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of monophenolase activity of mushroom tyrosinase assessed as inhibition constant for free enzyme-inhibitor complex by measuring reduction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50061554((+)-Silychristin | (2R,3R)-3,5,7-Trihydroxy-2-[(2R...)
Affinity DataKi:  2.10E+3nMAssay Description:Mixed type inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate by UV...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50061554((+)-Silychristin | (2R,3R)-3,5,7-Trihydroxy-2-[(2R...)
Affinity DataKi:  1.52E+4nMAssay Description:Inhibition of diphenolase activity of mushroom tyrosinase assessed as inhibition constant for free enzyme-inhibitor complex by measuring reduction in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50061554((+)-Silychristin | (2R,3R)-3,5,7-Trihydroxy-2-[(2R...)
Affinity DataKi:  1.54E+4nMAssay Description:Mixed type inhibition of diphenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA substrate by UV-Vis s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50061554((+)-Silychristin | (2R,3R)-3,5,7-Trihydroxy-2-[(2R...)
Affinity DataIC50:  3.64E+4nMAssay Description:Inhibition of OATP1B3 (unknown origin) expressed in HEK293 cells assessed as reduction of [3H]estradiol-17beta-glucuronide uptake after 3 mins by bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 2B1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50061554((+)-Silychristin | (2R,3R)-3,5,7-Trihydroxy-2-[(2R...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of OATP2B1 (unknown origin) expressed in MDCK2 cells assessed as reduction of [3H]estrone-3-sulfate uptake after 3 mins by beta-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50061554((+)-Silychristin | (2R,3R)-3,5,7-Trihydroxy-2-[(2R...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate by UV-Vis spectr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50061554((+)-Silychristin | (2R,3R)-3,5,7-Trihydroxy-2-[(2R...)
Affinity DataIC50:  2.88E+4nMAssay Description:Inhibition of diphenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA substrate by UV-Vis spectrophoto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50061554((+)-Silychristin | (2R,3R)-3,5,7-Trihydroxy-2-[(2R...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells assessed as reduction of [3H]estradiol-17beta-glucuronide uptake after 3 mins by bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Universidad De Alcalá

Curated by ChEMBL
LigandPNGBDBM50061554((+)-Silychristin | (2R,3R)-3,5,7-Trihydroxy-2-[(2R...)
Affinity DataIC50:  1.44E+5nMAssay Description:Inhibitory concentration of the compounds against Bovine trypsin enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed