BDBM50062351 (R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide::(R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide::(R)-N1-((S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide::3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE::CHEMBL19611::Ilomastat::US9487462, ilomastat
SMILES CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
InChI Key InChIKey=NITYDPDXAAFEIT-DYVFJYSZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 106 hits for monomerid = 50062351
Affinity DataKi: 0.180nMAssay Description:The compound was tested for its binding affinity towards neutrophil collagenase (Matrix metalloproteinase-8)More data for this Ligand-Target Pair
Affinity DataKi: 0.180nMAssay Description:Inhibition of MMP-8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Binding affinity towards 72 kDa gelatinase (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.570nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
Affinity DataKi: 0.570nMAssay Description:The compound was tested for its binding affinity towards 92 kDa gelatinase (Matrix metalloproteinase-9)More data for this Ligand-Target Pair
Affinity DataKi: 0.690nMAssay Description:Inhibition of human Matrix metalloproteinase-9More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Evaluated for inhibitory activity against Human fidroblast collagenase (HFC)More data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Inhibition of Matrix metalloproteinase-3More data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 46nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Stock solution of substrate (Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) was prepared in DMSO at a concentration of 6 mM. Assays were performed in an as...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Stock solution of substrate (Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) was prepared in DMSO at a concentration of 6 mM. Assays were performed in an as...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMpH: 7.5 T: 2°CAssay Description:Stock solution of substrate (Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) was prepared in DMSO at a concentration of 6 mM. Assays were performed in an as...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMpH: 7.5 T: 2°CAssay Description:Stock solution of substrate (Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) was prepared in DMSO at a concentration of 6 mM. Assays were performed in an as...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant 92 kDa gelatinase MMP-9 at 100 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of matrix metalloproteinase-9 (MMP-9)More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of matrix metalloproteinase-14 (MMP-14)More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Activity against Matrix metalloproteinase-9 (MMP-9).More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Activity against deletion mutant of MT1-MMP lacking the transmembrane domain (deltaMT1)More data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Activity against Matrix metalloproteinase-3 (MMP-3).More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Activity against Matrix metalloproteinase-2 (MMP-2).More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Activity against Matrix metalloproteinase-1 (MMP-1).More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against MMP14More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against MMP9More data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of MMP14 catalytic domainMore data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Universit£ di Pisa
Curated by ChEMBL
Universit£ di Pisa
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Inhibition of human recombinant ADAMTS4 expressed in HEk293 cells using FAM-AEwLQGRPISIAK-TAMRA as substrate measured for 15 mins by fluorometric ana...More data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Universit£ di Pisa
Curated by ChEMBL
Universit£ di Pisa
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant ADAMTS5 expressed in HEK293 cells using Abz-TESEwSRGAIY-Dpa-KK as substrate measured for 2 hrs by fluorometric analys...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of matrix metalloproteinase-1More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
Affinity DataIC50: 0.104nMAssay Description:Inhibition of human matrix metalloproteinase-2More data for this Ligand-Target Pair
Affinity DataIC50: 0.191nMAssay Description:Inhibition of human matrix metalloproteinase-3More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of matrix metalloproteinase-15 (MMP-15)More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of matrix metalloproteinase-26 (MMP-26)More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of matrix metalloproteinase-12 (MMP-12)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of matrix metalloproteinase-2 (MMP-2)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of matrix metalloproteinase-16 (MMP-16)More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Department Of Life Science And National Research Laboratory Of Proteolysis
Curated by ChEMBL
Department Of Life Science And National Research Laboratory Of Proteolysis
Curated by ChEMBL
Affinity DataIC50: 8.10nMAssay Description:In vitro inhibition of A disintegrin and metalloproteinase domain 10 (ADAM10)More data for this Ligand-Target Pair