BDBM50062357 AP26113::CHEMBL3397300

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N(C)C

InChI Key InChIKey=OVDSPTSBIQCAIN-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50062357   

LigandPNGBDBM50062357(AP26113 | CHEMBL3397300)
Affinity DataIC50:  66nMpH: 7.5Assay Description:Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Korea University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50062357(AP26113 | CHEMBL3397300)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Korea University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50062357(AP26113 | CHEMBL3397300)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50062357(AP26113 | CHEMBL3397300)
Affinity DataIC50:  5nMAssay Description:Inhibition of wild type EML4-ALK (unknown origin) expressed in mouse Ba/F3 cells assessed as cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062357(AP26113 | CHEMBL3397300)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Korea University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50062357(AP26113 | CHEMBL3397300)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062357(AP26113 | CHEMBL3397300)
Affinity DataIC50:  100nMAssay Description:Inhibition of human InsR using myelin basic protein as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed