BDBM50062397 3N-cyanoimino(tert-pentylamino)methyl-3-pyridinamine::3N-cyanoimino(tert-pentylamino)methyl-3-pyridinamineP1075)::CHEMBL11458::N''-cyano-N-(1,1-dimethylpropyl)-N'-pyridin-3-ylguanidine::N-cyano-N''-(1,1-dimethylpropyl)-N'-pyridin-3-ylguanidine::P-1075

SMILES CCC(C)(C)NC(NC#N)=Nc1cccnc1

InChI Key InChIKey=HKZNADVVGXKQDL-UHFFFAOYSA-N

Data  1 KI  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50062397   

TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062397(3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)
Affinity DataKi:  27nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062397(3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)
Affinity DataEC50:  85nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062397(3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)
Affinity DataEC50:  52nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062397(3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)
Affinity DataEC50:  22nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50062397(3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)
Affinity DataEC50:  230nMAssay Description:Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit gamma, mitochondrial(Bos taurus)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062397(3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration towards rat mitochondrial F1F0 ATP hydrolase using a pyruvate kinase / lactate dehydrogenase systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed