BDBM50062410 2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL101914

SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(c4ccccc4)c3c12

InChI Key InChIKey=KGVGNTCIQIYLQU-UHFFFAOYSA-N

Data  4 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50062410   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062410(2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity against human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062410(2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataKi:  3.60nMAssay Description:The binding affinity of the compound was determined on Human progesterone receptor (hPR-A) using progesterone as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062410(2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataKi:  154nMAssay Description:Binding affinity was determined on Human glucocorticoid receptor (hAR) using progesterone as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062410(2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataKi:  1.86E+3nMAssay Description:Binding affinity was determined on Human androgen receptor (hAR) using progesterone as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062410(2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataIC50:  745nMAssay Description:Antagonistic activity was determined in Human androgen receptor(hAR) of CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062410(2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataEC50:  156nMAssay Description:Effective concentration (EC50) against human progesterone receptor expressed in CV-1 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062410(2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataIC50:  354nMAssay Description:Antagonistic activity was determined in Human mineralocorticoid receptor(hMR) of CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062410(2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataIC50:  226nMAssay Description:Antagonistic activity was determined in Human glucocorticoid receptor(hGR) of CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062410(2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataEC50:  156nMAssay Description:Agonistic activity to the human progesterone receptor(hPR)assayed in CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062410(2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataIC50:  290nMAssay Description:Antagonistic activity was determined in Human progesterone receptor(hPR) of CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed