BDBM50063372 1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone::CHEMBL305798

SMILES [O-][n+]1ccc(CC(=O)N2CCN(CC2)[C@H]2c3ccc(Cl)cc3CCc3cc(Br)cnc23)cc1

InChI Key InChIKey=UHGZCRVPTZSYOB-VWLOTQADSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50063372   

TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063372(1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogeneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063372(1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...)
Affinity DataIC50:  125nMAssay Description:Inhibition of Farnesyltransferase from Ras-CVLS or Ras-CVLL in Cos-7 monkey kidney cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063372(1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...)
Affinity DataIC50:  1.50E+3nMAssay Description:In vitro inhibition of Ha-ras farnesylation in Ha-ras-transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063372(1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Farnesyl protein transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063372(1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...)
Affinity DataIC50:  6.50E+3nMAssay Description:In vitro inhibition of Ha-ras farnesylation in Ki-ras-transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063372(1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...)
Affinity DataIC50:  8.00E+3nMAssay Description:In vitro inhibition of Ha-ras farnesylation in DLD-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus (rat))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063372(1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...)
Affinity DataIC50: >7.60E+4nMAssay Description:Inhibition of rat Geranylgeranyl transferase (GGPT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063372(1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...)
Affinity DataIC50:  7.00E+3nMAssay Description:In vitro inhibition of Ha-ras farnesylation in DLD-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed