BDBM50063716 2-Amino-benzo[d][1,3]oxazin-4-one::CHEMBL268763

SMILES Nc1nc2ccccc2c(=O)o1

InChI Key InChIKey=YYPXNAAEYOJYES-UHFFFAOYSA-N

Data  2 KI  1 IC50  2 Koff  1 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50063716   

TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063716(2-Amino-benzo[d][1,3]oxazin-4-one | CHEMBL268763)
Affinity DataKi:  6.30E+4nMAssay Description:Rate of deacylation by human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063716(2-Amino-benzo[d][1,3]oxazin-4-one | CHEMBL268763)
Affinity DataKi:  6.31E+4nM Kon:  0.0513M-1s-1 Koff:  813s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063716(2-Amino-benzo[d][1,3]oxazin-4-one | CHEMBL268763)
Affinity DataKon:  0.0510M-1s-1Assay Description:Rate of deacylation by human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063716(2-Amino-benzo[d][1,3]oxazin-4-one | CHEMBL268763)
Affinity DataIC50: >6.25E+4nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed