BDBM50065287 5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one::5-Nitro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL87325

SMILES [O-][N+](=O)c1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1

InChI Key InChIKey=UUKMQWDTHJLSMU-WDZFZDKYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50065287   

TargetVascular endothelial growth factor receptor 2(Mus musculus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50065287(5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-in...)
Affinity DataIC50:  1.00E+6nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065287(5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-in...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065287(5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-in...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065287(5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-in...)
Affinity DataIC50:  710nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065287(5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-in...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065287(5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-in...)
Affinity DataIC50:  4.17E+4nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065287(5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-in...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed