BDBM50065454 CHEBI:63453::CHEMBL3348846

SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1

InChI Key InChIKey=VRQMAABPASPXMW-HDICACEKSA-N

Data  79 IC50  3 Kd  2 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 84 hits for monomerid = 50065454   

TargetFibroblast growth factor receptor 4(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of FGFR4 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  27nMAssay Description:Inhibition of FGFR3 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of FGFR2 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of FGFR1 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
Chinese Academy of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of recombinant FGFR3 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  46nMAssay Description:Inhibition of recombinant FGFR4 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  33nMAssay Description:Inhibition of FGFR1 in human H1581 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50: <0.200nMAssay Description:Inhibition of FGFR1 in human KG1 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  20nMAssay Description:Inhibition of FGFR2 in human KATO III cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of FGFR3 in human RT112 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of recombinant FGFR2 in human SNU16 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant FGFR2 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
Chinese Academy of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  27nMAssay Description:Inhibition of recombinant human VEGFR2 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  165nMAssay Description:Inhibition of recombinant human FGFR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant human FGFR1 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  165nMAssay Description:Inhibition of recombinant human FGFR4 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of recombinant human FGFR3 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of recombinant human FGFR2 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  63nMAssay Description:Inhibition of FGFR1 in human NCI-H1581 cells assessed as inhibition of cell proliferation after 72 hrs by cell counting kit-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of recombinant human FGFR3 using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant human FGFR2 using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  16nMAssay Description:Inhibition of FGFR1OP2 fused FGFR1 in human KG1 cells assessed as inhibition of cell proliferation after 72 hrs by cell counting kit-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  14nMAssay Description:Inhibition of FGFR2 in human KATO III cells assessed as inhibition of cell proliferation after 72 hrs by cell counting kit-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  25nMAssay Description:Compound was tested for binding affinity to dopamine reuptake sites in the tissue homogenates prepared from primate rat striatum using [3H]CFT as rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.700nMAssay Description:Binding activity against rat muscarinic acetylcholine receptor M3 using [3H]QNB as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  27nMAssay Description:Inhibition of FGFR3 in human RT112 cells assessed as inhibition of cell proliferation after 72 hrs by cell counting kit-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of FGFR1 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant FGFR2 (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISA based spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISA based spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA based spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human FGFR3 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  50nMAssay Description:Inhibition of human FGFR4 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human FGFR2 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
Chinese Academy of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  58nMAssay Description:Inhibition of human VEGFR2 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human FGFR1 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  165nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of FGFR1 (unknown origin) after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of FGFR1 (unknown origin) after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human FGFR2 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  46nMAssay Description:Inhibition of human FGFR4 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  165nMAssay Description:Inhibition of human FGFR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human FGFR2 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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