BDBM50065454 CHEBI:63453::CHEMBL3348846
SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1
InChI Key InChIKey=VRQMAABPASPXMW-HDICACEKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 79 hits for monomerid = 50065454
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of FGFR4 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of FGFR3 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of FGFR2 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR1 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)
Curated by ChEMBL
Chinese Academy Of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of recombinant FGFR3 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant FGFR4 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of FGFR1 in human H1581 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: <0.200nMAssay Description:Inhibition of FGFR1 in human KG1 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of FGFR2 in human KATO III cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of FGFR3 in human RT112 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant FGFR2 in human SNU16 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant FGFR2 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)
Curated by ChEMBL
Chinese Academy Of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human VEGFR2 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 165nMAssay Description:Inhibition of recombinant human FGFR4More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 in presence of ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 165nMAssay Description:Inhibition of recombinant human FGFR4 in presence of ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human FGFR3 in presence of ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human FGFR2 in presence of ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of FGFR1 in human NCI-H1581 cells assessed as inhibition of cell proliferation after 72 hrs by cell counting kit-8 assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Inhibition of recombinant human FGFR3 using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human FGFR2 using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of FGFR1OP2 fused FGFR1 in human KG1 cells assessed as inhibition of cell proliferation after 72 hrs by cell counting kit-8 assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of FGFR2 in human KATO III cells assessed as inhibition of cell proliferation after 72 hrs by cell counting kit-8 assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Compound was tested for binding affinity to dopamine reuptake sites in the tissue homogenates prepared from primate rat striatum using [3H]CFT as rad...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Binding activity against rat muscarinic acetylcholine receptor M3 using [3H]QNB as the radioligandMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of FGFR3 in human RT112 cells assessed as inhibition of cell proliferation after 72 hrs by cell counting kit-8 assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FGFR1 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant FGFR2 (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISA based spectrophotometric analysisMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISA based spectrophotometric analysisMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA based spectrophotometric methodMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human FGFR3 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human FGFR4 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human FGFR2 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)
Curated by ChEMBL
Chinese Academy Of Sciences (Cas)
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of human VEGFR2 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human FGFR1 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 165nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FGFR1 (unknown origin) after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FGFR1 (unknown origin) after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human FGFR2 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of human FGFR4 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 165nMAssay Description:Inhibition of human FGFR4More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human FGFR2 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Health Science Center Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair