BDBM50068649 CHEMBL3402361::US10828301, Compound R921302

SMILES Nc1cccc(Nc2ncc(F)c(Nc3cccc(N)c3)n2)c1

InChI Key InChIKey=VDYYZYAHNFWOPX-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50068649   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM50068649(CHEMBL3402361 | US10828301, Compound R921302)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in ionomycin-induced calcium mobilization mediated degranulation by tryptase rele...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM50068649(CHEMBL3402361 | US10828301, Compound R921302)
Affinity DataIC50:  268nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM50068649(CHEMBL3402361 | US10828301, Compound R921302)
Affinity DataIC50:  320nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM50068649(CHEMBL3402361 | US10828301, Compound R921302)
Affinity DataEC50:  460nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed