BDBM50068762 2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-one::CHEMBL127101

SMILES COc1ccc(cc1)-c1nc2c(C)cccc2c(=O)[nH]1

InChI Key InChIKey=HTLUBFSSIMOABR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50068762   

TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068762(2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-one ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant IMPDH2 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068762(2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-one ...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human tankyrase1 after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068762(2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-one ...)
Affinity DataIC50:  891nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 hr by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Mouse)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068762(2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-one ...)
Affinity DataIC50:  190nMAssay Description:Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068762(2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-one ...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human tankyrase2 after 2 hrs by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed