BDBM50069068 (R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-pyrrolo[3,2-g]quinolin-7-one::CHEMBL351465

SMILES C[C@@H]1Cc2cc3c(cc(=O)[nH]c3cc2N1)C(F)(F)F

InChI Key InChIKey=UDMCMALCRGIISA-ZCFIWIBFSA-N

Data  1 KI  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50069068   

TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069068((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...)
Affinity DataKi:  10nMAssay Description:Binding affinity against Androgen receptor transfected into COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069068((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonistic activity against hMR in cotransfected CV-1 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069068((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonistic activity against Glucocorticoid receptor in cotransfected CV-1 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069068((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...)
Affinity DataIC50:  7nMAssay Description:Antagonistic activity (IC50) against human androgen receptor (hAR) in cotransfected CV-1 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069068((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonistic activity against Estrogen receptor in co-transfected CV-1 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069068((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...)
Affinity DataEC50:  168nMAssay Description:Agonistic activity (EC50) against human androgen receptor (hAR) in cotransfected CV-1 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069068((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...)
Affinity DataIC50:  750nMAssay Description:Antagonistic activity against hPR in cotransfected CV-1 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed