BDBM50071708 4-{2-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide::CHEMBL313193

SMILES [#7]-[#6](=O)-[#7]-1-[#6]-[#6]-[#6](-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2\c3ccc(Cl)cc3-[#16]-[#6]-c3cccnc-23)-[#6]-[#6]-1

InChI Key InChIKey=VSRQOGRWFBCHEX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50071708   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071708(4-{2-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cy...)
Affinity DataIC50:  920nMAssay Description:In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071708(4-{2-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cy...)
Affinity DataIC50:  3.80E+3nMAssay Description:In vitro inhibition of Ras processing in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed