BDBM50071715 1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone::CHEMBL315067

SMILES Clc1ccc2c(-[#16]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1

InChI Key InChIKey=PTQDPYKHPIFXEQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50071715   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071715(1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclo...)
Affinity DataIC50:  190nMAssay Description:In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071715(1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclo...)
Affinity DataIC50:  4.20E+3nMAssay Description:In vitro inhibition of Ras processing in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed