BDBM50073691 2-(5-Methyl-1H-indol-3-yl)-ethylamine::5-Methyl-tryptamine, 10::5-Methyltryptamine::CHEMBL331241::EN300-651516

SMILES Cc1ccc2[nH]cc(CCN)c2c1

InChI Key InChIKey=PYOUAIQXJALPKW-UHFFFAOYSA-N

Data  4 KI  3 IC50  1 Kd  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50073691   

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataKi:  6.40nMAssay Description:In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(RAT)
University Of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataKi:  33.1nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataKi:  3.22E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataKi:  6.15E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataIC50:  1.63E+3nMAssay Description:IC50 values were determined for the whole plate in case of Chan-Lam coupling, using 5 point 3-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataIC50:  80nMAssay Description:IC50 values were determined using 12 point 2-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of DAT-mediated dopamine release in rat brain synaptosomes by [3H]DA release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of NET-mediated norepinephrine release in rat brain synaptosomes by [3H]NE release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataIC50:  70nMAssay Description:IC50 values were determined using 12 point 2-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrp operon repressor(Escherichia coli (strain K12))
University Of Chicago

LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataKd:  2.88E+4nMAssay Description:Binding assay of L-trptophan and analogues to trp aporepressorMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50073691(2-(5-Methyl-1H-indol-3-yl)-ethylamine | 5-Methyl-t...)
Affinity DataEC50:  139nMAssay Description:Induction of 5-HTT-mediated 5-HT release in rat brain synaptosomes by [3H]5-HT release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed