BDBM50073761 CHEMBL368278::N*2*-((1S,3R)-3-Amino-cyclohexyl)-N*6*-(3-chloro-phenyl)-9-ethyl-9H-purine-2,6-diamine

SMILES CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCC[C@@H](N)C3)nc12

InChI Key InChIKey=JXZIZOIXGMUPSK-HIFRSBDPSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50073761   

TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073761(CHEMBL368278 | N*2*-((1S,3R)-3-Amino-cyclohexyl)-N...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against cyclin-dependent kinase 1 (CDK1) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073761(CHEMBL368278 | N*2*-((1S,3R)-3-Amino-cyclohexyl)-N...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibit of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073761(CHEMBL368278 | N*2*-((1S,3R)-3-Amino-cyclohexyl)-N...)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibition of Protein kinase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073761(CHEMBL368278 | N*2*-((1S,3R)-3-Amino-cyclohexyl)-N...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed