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BDBM50074087 CHEMBL1076266::CHEMBL157493::sec-Butyl-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester; compound with (E)-but-2-enedioic acid

SMILES: CCC(C)NC(=O)OCCCc1cnc[nH]1

InChI Key: InChIKey=RSHJCGZZSGNBHO-UHFFFAOYNA-N

Data: 3 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50074087   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074087
PNG
(CHEMBL1076266 | CHEMBL157493 | sec-Butyl-carbamic ...)
Show SMILES CCC(C)NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1/C11H19N3O2/c1-3-9(2)14-11(15)16-6-4-5-10-7-12-8-13-10/h7-9H,3-6H2,1-2H3,(H,12,13)(H,14,15)
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UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Effect at histamine H3 receptors (in vitro) on synaptosomes of rat cerebral cortex assayed by functional H3-receptor assay.


J Med Chem 42: 593-600 (1999)


Article DOI: 10.1021/jm9804376
BindingDB Entry DOI: 10.7270/Q2GH9H4J
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074087
PNG
(CHEMBL1076266 | CHEMBL157493 | sec-Butyl-carbamic ...)
Show SMILES CCC(C)NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1/C11H19N3O2/c1-3-9(2)14-11(15)16-6-4-5-10-7-12-8-13-10/h7-9H,3-6H2,1-2H3,(H,12,13)(H,14,15)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from histamine H3 receptor in rat cerebral cortex


Bioorg Med Chem Lett 19: 6682-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.005
BindingDB Entry DOI: 10.7270/Q2GM87DG
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50074087
PNG
(CHEMBL1076266 | CHEMBL157493 | sec-Butyl-carbamic ...)
Show SMILES CCC(C)NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1/C11H19N3O2/c1-3-9(2)14-11(15)16-6-4-5-10-7-12-8-13-10/h7-9H,3-6H2,1-2H3,(H,12,13)(H,14,15)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
49n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cells


Bioorg Med Chem Lett 19: 6682-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.005
BindingDB Entry DOI: 10.7270/Q2GM87DG
More data for this
Ligand-Target Pair