BDBM50077323 7,4'-Dihydroxyflavone::7-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one::CHEMBL294878

SMILES Oc1ccc(cc1)-c1cc(=O)c2ccc(O)cc2o1

InChI Key InChIKey=LCAWNFIFMLXZPQ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50077323   

TargetBeta-glucuronidase(Rat)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50077323(7,4'-Dihydroxyflavone | 7-hydroxy-2-(4-hydroxyphen...)
Affinity DataIC50:  1.37E+4nMAssay Description:Inhibitory effect of compound on the release of Beta-glucuronidase in rat neutrophils stimulated with fMLP/CBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLysozyme C-1(Rat)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50077323(7,4'-Dihydroxyflavone | 7-hydroxy-2-(4-hydroxyphen...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibitory effect of compound on the release of lysozyme in rat neutrophils stimulated with fMLP/CBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50077323(7,4'-Dihydroxyflavone | 7-hydroxy-2-(4-hydroxyphen...)
Affinity DataIC50:  1.36E+4nMAssay Description:Inhibition of ALR2 (aldose reductase) of bovine lensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50077323(7,4'-Dihydroxyflavone | 7-hydroxy-2-(4-hydroxyphen...)
Affinity DataIC50:  7.86E+5nMAssay Description:Inhibition of p56 lckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInositol hexakisphosphate kinase 2(Human)
National Institute of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50077323(7,4'-Dihydroxyflavone | 7-hydroxy-2-(4-hydroxyphen...)
Affinity DataIC50:  1.83E+4nMAssay Description:Inhibition of human IP6K2 using insP6 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSialidase-2(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50077323(7,4'-Dihydroxyflavone | 7-hydroxy-2-(4-hydroxyphen...)
Affinity DataIC50:  4.70E+5nMAssay Description:Inhibition of human Neu2 assessed as MuNANA substrate hydrolysis in presence of 0.1% Triton X-100 by discontinuous fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAromatase(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50077323(7,4'-Dihydroxyflavone | 7-hydroxy-2-(4-hydroxyphen...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human placental microsome CYP19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMyeloperoxidase(Human)
Free University of Brussels

Curated by ChEMBL
LigandPNGBDBM50077323(7,4'-Dihydroxyflavone | 7-hydroxy-2-(4-hydroxyphen...)
Affinity DataIC50:  5.79E+3nMAssay Description:Inhibition of cathepsin D.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInositol polyphosphate multikinase(Human)
National Institute of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50077323(7,4'-Dihydroxyflavone | 7-hydroxy-2-(4-hydroxyphen...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human IPMK using insP3 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutaminyl-peptide cyclotransferase(Human)
Shenzhen University

Curated by ChEMBL
LigandPNGBDBM50077323(7,4'-Dihydroxyflavone | 7-hydroxy-2-(4-hydroxyphen...)
Affinity DataIC50:  4.52E+4nMAssay Description:Inhibition of human recombinant glutaminyl cyclase expressed in Escherichia coli using H-Gln-Gln-H substrate measured for 15 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed