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BDBM50078633 CHEMBL3415187

SMILES: Cn1cc(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1

InChI Key: InChIKey=MHCGPMADKRLTON-UHFFFAOYSA-N

Data: 2 IC50  3 Kd

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50078633   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078633
PNG
(CHEMBL3415187)
Show SMILES Cn1cc(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C19H17N7/c1-24-10-15(8-22-24)11-26-13-21-18(17-9-23-25(2)12-17)19(26)16-5-3-14(7-20)4-6-16/h3-6,8-10,12-13H,11H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens (Human))
BDBM50078633
PNG
(CHEMBL3415187)
Show SMILES Cn1cc(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C19H17N7/c1-24-10-15(8-22-24)11-26-13-21-18(17-9-23-25(2)12-17)19(26)16-5-3-14(7-20)4-6-16/h3-6,8-10,12-13H,11H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 109n/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2A (unknown origin) by isothermal titration calorimetric analysis


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens (Human))
BDBM50078633
PNG
(CHEMBL3415187)
Show SMILES Cn1cc(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C19H17N7/c1-24-10-15(8-22-24)11-26-13-21-18(17-9-23-25(2)12-17)19(26)16-5-3-14(7-20)4-6-16/h3-6,8-10,12-13H,11H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 130n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Cat eye syndrome critical region protein 2


(Homo sapiens (Human))
BDBM50078633
PNG
(CHEMBL3415187)
Show SMILES Cn1cc(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C19H17N7/c1-24-10-15(8-22-24)11-26-13-21-18(17-9-23-25(2)12-17)19(26)16-5-3-14(7-20)4-6-16/h3-6,8-10,12-13H,11H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.55E+3n/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CECR2 (unknown origin) by isothermal titration calorimetric analysis


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2B


(Homo sapiens (Human))
BDBM50078633
PNG
(CHEMBL3415187)
Show SMILES Cn1cc(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C19H17N7/c1-24-10-15(8-22-24)11-26-13-21-18(17-9-23-25(2)12-17)19(26)16-5-3-14(7-20)4-6-16/h3-6,8-10,12-13H,11H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 170n/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2B (unknown origin) by isothermal titration calorimetric analysis


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair