BDBM50082058 5-(3,5-Difluoro-phenyl)-5-ethyl-6-oxa-10b-aza-benzo[e]azulen-4-one::CHEMBL141371

SMILES CCC1(Oc2ccccc2-n2cccc2C1=O)c1cc(F)cc(F)c1

InChI Key InChIKey=XOTGYWLVTZICLR-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50082058   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082058(5-(3,5-Difluoro-phenyl)-5-ethyl-6-oxa-10b-aza-benz...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibitory activity against HIV-1 wild type reverse transcriptase (RT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082058(5-(3,5-Difluoro-phenyl)-5-ethyl-6-oxa-10b-aza-benz...)
Affinity DataKi:  1.70E+3nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution L100IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082058(5-(3,5-Difluoro-phenyl)-5-ethyl-6-oxa-10b-aza-benz...)
Affinity DataKi:  2.70E+3nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution K103NMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082058(5-(3,5-Difluoro-phenyl)-5-ethyl-6-oxa-10b-aza-benz...)
Affinity DataKi:  3.00E+3nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution V106AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082058(5-(3,5-Difluoro-phenyl)-5-ethyl-6-oxa-10b-aza-benz...)
Affinity DataKi:  6.80E+3nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution Y181IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082058(5-(3,5-Difluoro-phenyl)-5-ethyl-6-oxa-10b-aza-benz...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution Y188LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed