BDBM50083639 CHEMBL112346::{4-[6-((S)-3-Ethyl-piperazin-1-yl)-pyridin-3-yl]-pyrimidin-2-yl}-(3,4,5-trimethoxy-phenyl)-amine

SMILES CC[C@H]1CN(CCN1)c1ccc(cn1)-c1ccnc(Nc2cc(OC)c(OC)c(OC)c2)n1

InChI Key InChIKey=YTOUFEQLXOWLSL-KRWDZBQOSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50083639   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083639(CHEMBL112346 | {4-[6-((S)-3-Ethyl-piperazin-1-yl)-...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083639(CHEMBL112346 | {4-[6-((S)-3-Ethyl-piperazin-1-yl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of csk tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083639(CHEMBL112346 | {4-[6-((S)-3-Ethyl-piperazin-1-yl)-...)
Affinity DataIC50:  2.87E+3nMAssay Description:Inhibition of protein kinase C (PKC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083639(CHEMBL112346 | {4-[6-((S)-3-Ethyl-piperazin-1-yl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083639(CHEMBL112346 | {4-[6-((S)-3-Ethyl-piperazin-1-yl)-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed