BDBM50085048 (S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyridin-2-yl-amino)-ethoxy]-phenyl}-propionic acid::(S)-2-(2-benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid::2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyridin-2-yl-amino)-ethoxy]-phenyl}-propionic acid::CHEMBL434063
SMILES CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1ccccn1
InChI Key InChIKey=QTQMRBZOBKYXCG-MHZLTWQESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 31 hits for monomerid = 50085048
Affinity DataKi: 0.0497nMAssay Description:Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARgamma LBD by TR-FRET assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.430nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET-based competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Lanthascreen TR-FRET assay relative to controlMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET based LanthaScreen competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 104nMAssay Description:In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assa...Checked by AuthorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataKi: <5.50E+3nMAssay Description:The compound was tested in vitro for inhibiting the 50% binding of Peroxisome proliferator activated receptor alphaChecked by AuthorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataKi: 6.15E+3nMAssay Description:The compound was tested in vitro for inhibiting the 50% binding of Peroxisome proliferator activated receptor deltaChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 8.84E+3nMAssay Description:Tested for its ability to bind to Peroxisome proliferator activated receptor gamma using [3H]-BRL 49653 as radioligand in scintillation proximity ass...Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 1.13E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonist activity at human PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 26nMAssay Description:Binding affinity to PPARgamma LBD by fluorescence polarization based competitive binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.70nMAssay Description:Displacement of pan-PPAR fluormone from PPARgamma LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataEC50: 5.53E+4nMAssay Description:Displacement of pan-PPAR fluormone from PPARalpha LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 389nMAssay Description:Activation of peroxisome proliferator activated receptor gamma measured by induction of 50% of maximum alkaline phosphatase activity, transfection as...Checked by AuthorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataEC50: 13nMAssay Description:Compound was tested functionally in vitro for inducing 50% of the maximum alkaline phosphatase activity (Transactivation) against murine Peroxisome p...Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Competitive binding affinity to GST-tagged human PPARgamma LBD incubated for 1 to 6 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide C33 by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at human PPAR-gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide fluorescein-TRAP220/DRIP by TR-FRET ass...More data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at PPARgamma (unknown origin) assessed as increase in fluorescein labeled TRAP220/DRIP-2 coactivator peptide requirement by Lanthasc...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at PPARgamma (unknown origin) assessed as increase in fluorescein labeled PRIP/RAP250 coactivator peptide requirement by Lanthascree...More data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Ability to promote differentiation of C3H10T1/2 stem cells to adipocytes using lipogenesis assay mediated through activation of Peroxisome proliferat...Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Partial agonist activity at PPARgamma (unknown origin) assessed as increase in fluorescein labeled PRIP/RAP250 coactivator peptide requirement by Lan...More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator RAP250 to PPARgamma LBD by TR-FRET-based nuclea...More data for this Ligand-Target Pair
Affinity DataEC50: 389nMAssay Description:Activation of peroxisome proliferator activated receptor gamma measured by induction of 50% of maximum alkaline phosphatase activity, transfection as...Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataEC50: 6.20nMAssay Description:Agonist activity for Human PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataEC50: 13nMAssay Description:Agonist activity for murine PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataEC50: 13nMAssay Description:Agonist activity at mouse PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair