BDBM50088804 1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethyl)benzoyl)-::2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione::2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione::CHEMBL1337::NITISINONE

SMILES [O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F

InChI Key InChIKey=OUBCNLGXQFSTLU-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50088804   

Target4-hydroxyphenylpyruvate dioxygenase(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50088804(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
Affinity DataKi:  37nMAssay Description:Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target4-hydroxyphenylpyruvate dioxygenase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50088804(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Wistar rat liver cytosol HPPD using HPP as substrate assessed as reduction in O2 consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target4-hydroxyphenylpyruvate dioxygenase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50088804(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Wistar rat liver HPPD using 4-Hydroxyphenylpyruvate as substrate assessed as reduction in oxygen consumption preincubated for 3 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target4-hydroxyphenylpyruvate dioxygenase(Pig)
Tunghai Christian University

Curated by ChEMBL
LigandPNGBDBM50088804(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
Affinity DataIC50:  40nMAssay Description:Inhibition of 4-hydroxyphenylpyruvate dioxygenase of purified pig liver by enol-borate methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed