BDBM50088900 5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine::CGP-62464::CHEMBL169757

SMILES Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccccc1

InChI Key InChIKey=AFVGAHBUCVDPPI-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50088900   

TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine ...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PDGF-receptor kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine ...)
Affinity DataIC50:  3.00E+3nMAssay Description:Tested for inhibition of EGF-receptor tyrosine kinase in intact cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine ...)
Affinity DataIC50:  5.40E+4nMAssay Description:Tested in vitro for inhibition of serine/threonine kinase Cdc2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine ...)
Affinity DataIC50:  100nMAssay Description:Tested for inhibition of protein tyrosine kinase c-Src phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine ...)
Affinity DataIC50:  500nMAssay Description:Tested in vitro for inhibition of KDR-receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM50088900(5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine ...)
Affinity DataIC50:  100nMAssay Description:Inhibition of c-Src kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine ...)
Affinity DataIC50: >5.00E+3nMAssay Description:Tested for inhibition of protein tyrosine kinase Csk phosphorylation in intact cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine ...)
Affinity DataIC50:  100nMAssay Description:Inhibition of p60 c-Src tyrosine kinase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine ...)
Affinity DataIC50:  500nMAssay Description:Tested in vitro for inhibition of non-receptor tyrosine kinase v-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM50088900(5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine ...)
Affinity DataIC50:  100nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM50088900(5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine ...)
Affinity DataIC50:  3.50E+3nMAssay Description:Tested for inhibition of protein tyrosine kinase c-Src phosphorylation in intact cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed