BDBM50091635 5-{3-[4-(3-Fluoro-benzyl)-piperidin-1-yl]-prop-1-ynyl}-1,3-dihydro-benzoimidazol-2-one::CHEMBL19636

SMILES Fc1cccc(CC2CCN(CC#Cc3ccc4[nH]c(=O)[nH]c4c3)CC2)c1

InChI Key InChIKey=MIIJMODVRMTWJP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50091635   

TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
Cocensys

Curated by ChEMBL
LigandPNGBDBM50091635(5-{3-[4-(3-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Affinity DataIC50:  6.10nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
Cocensys

Curated by ChEMBL
LigandPNGBDBM50091635(5-{3-[4-(3-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2C NMDA expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50091635(5-{3-[4-(3-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Affinity DataIC50:  14nMAssay Description:Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Cocensys

Curated by ChEMBL
LigandPNGBDBM50091635(5-{3-[4-(3-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Affinity DataIC50:  3.90E+3nMAssay Description:Displacement of [3H]-raclopride at Dopamine receptor D2 in brain striata (n=1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
Cocensys

Curated by ChEMBL
LigandPNGBDBM50091635(5-{3-[4-(3-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2A NMDA expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed