BDBM50092254 7-Isopropyl-5-[4-(2-nitro-phenoxy)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::CHEMBL304113

SMILES CC(C)n1cc(-c2ccc(Oc3ccccc3[N+]([O-])=O)cc2)c2c(N)ncnc12

InChI Key InChIKey=PWEMILVNKQAISL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50092254   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092254(7-Isopropyl-5-[4-(2-nitro-phenoxy)-phenyl]-7H-pyrr...)
Affinity DataIC50:  900nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR2) at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092254(7-Isopropyl-5-[4-(2-nitro-phenoxy)-phenyl]-7H-pyrr...)
Affinity DataIC50:  38nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092254(7-Isopropyl-5-[4-(2-nitro-phenoxy)-phenyl]-7H-pyrr...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory activity against tie-2 at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092254(7-Isopropyl-5-[4-(2-nitro-phenoxy)-phenyl]-7H-pyrr...)
Affinity DataIC50: <3nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed