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BDBM50092271 (Z)-5-Benzylidene-2-thioxothiazolidin-4-one::(Z)-5-phenyl-2-thioxothiazolidin-4-one::5-[1-Phenyl-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one::5-benzylidene-2-thioxothiazolidin-4-one::CHEMBL305763

SMILES: SC1=NC(=O)C(S1)=Cc1ccccc1

InChI Key: InChIKey=OONWCXLYKDWKOU-UHFFFAOYSA-N

Data: 4 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50092271   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arylamine N-acetyltransferase 1


(Homo sapiens)
BDBM50092271
PNG
((Z)-5-Benzylidene-2-thioxothiazolidin-4-one | (Z)-...)
Show SMILES SC1=NC(=O)C(S1)=Cc1ccccc1
Show InChI InChI=1S/C10H7NOS2/c12-9-8(14-10(13)11-9)6-7-4-2-1-3-5-7/h1-6H,(H,11,12,13)
PDB
MMDB

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Article
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NAT1 assessed as hydrolysis of acetyl coA using PABA as substrate by Ellman's method


Bioorg Med Chem 17: 905-18 (2009)


Article DOI: 10.1016/j.bmc.2008.11.032
BindingDB Entry DOI: 10.7270/Q2PZ58Q3
More data for this
Ligand-Target Pair
Beta-lactamase TEM


(Enterobacter cloacae)
BDBM50092271
PNG
((Z)-5-Benzylidene-2-thioxothiazolidin-4-one | (Z)-...)
Show SMILES SC1=NC(=O)C(S1)=Cc1ccccc1
Show InChI InChI=1S/C10H7NOS2/c12-9-8(14-10(13)11-9)6-7-4-2-1-3-5-7/h1-6H,(H,11,12,13)
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Article
PubMed
n/an/a>7.00E+5n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coli


Bioorg Med Chem Lett 10: 2179-82 (2001)


Article DOI: 10.1016/s0960-894x(00)00444-3
BindingDB Entry DOI: 10.7270/Q2T15456
More data for this
Ligand-Target Pair
Beta-lactamase


(Enterobacter cloacae)
BDBM50092271
PNG
((Z)-5-Benzylidene-2-thioxothiazolidin-4-one | (Z)-...)
Show SMILES SC1=NC(=O)C(S1)=Cc1ccccc1
Show InChI InChI=1S/C10H7NOS2/c12-9-8(14-10(13)11-9)6-7-4-2-1-3-5-7/h1-6H,(H,11,12,13)
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Article
PubMed
n/an/a 4.55E+5n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against class C Beta-lactamase isolated from Enterobacter cloacae


Bioorg Med Chem Lett 10: 2179-82 (2001)


Article DOI: 10.1016/s0960-894x(00)00444-3
BindingDB Entry DOI: 10.7270/Q2T15456
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50092271
PNG
((Z)-5-Benzylidene-2-thioxothiazolidin-4-one | (Z)-...)
Show SMILES SC1=NC(=O)C(S1)=Cc1ccccc1
Show InChI InChI=1S/C10H7NOS2/c12-9-8(14-10(13)11-9)6-7-4-2-1-3-5-7/h1-6H,(H,11,12,13)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of Electrophorus electricus acetylcholinesterase preincubated for 15 mins by spectrophotometry


Bioorg Med Chem 19: 7453-63 (2011)


Article DOI: 10.1016/j.bmc.2011.10.042
BindingDB Entry DOI: 10.7270/Q2WQ0468
More data for this
Ligand-Target Pair