BDBM50092324 CHEMBL3581655::US9675697, Cpd. No. 1

SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)noc3C)c21

InChI Key InChIKey=ZBKQIKDKLUJFMK-UHFFFAOYSA-N

Data  8 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50092324   

TargetBromodomain-containing protein 3 [326-398](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM50092324(CHEMBL3581655 | US9675697, Cpd. No. 1)
Affinity DataKi:  14nM ΔG°:  -10.7kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 3 [51-123](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM50092324(CHEMBL3581655 | US9675697, Cpd. No. 1)
Affinity DataKi:  15nM ΔG°:  -10.7kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [91-163](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM50092324(CHEMBL3581655 | US9675697, Cpd. No. 1)
Affinity DataKi:  32nM ΔG°:  -10.2kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [364-436](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM50092324(CHEMBL3581655 | US9675697, Cpd. No. 1)
Affinity DataKi:  35nM ΔG°:  -10.2kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50092324(CHEMBL3581655 | US9675697, Cpd. No. 1)
Affinity DataKi:  48nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD1 (44 to 168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM50092324(CHEMBL3581655 | US9675697, Cpd. No. 1)
Affinity DataKi:  48nM ΔG°:  -9.98kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [364-436](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM50092324(CHEMBL3581655 | US9675697, Cpd. No. 1)
Affinity DataKi:  70nM ΔG°:  -9.75kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50092324(CHEMBL3581655 | US9675697, Cpd. No. 1)
Affinity DataKi:  70nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD2 (333 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50092324(CHEMBL3581655 | US9675697, Cpd. No. 1)
Affinity DataIC50:  134nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD1 (44 to 168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50092324(CHEMBL3581655 | US9675697, Cpd. No. 1)
Affinity DataIC50:  221nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD2 (333 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed