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BDBM50094238 CHEMBL3589689

SMILES: [#6]-c1c(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)c2ccccc2n1-[#6]-c1ccc(Br)cc1

InChI Key: InChIKey=HETSSARHFAGODR-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50094238   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)


(Homo sapiens (Human))
BDBM50094238
PNG
(CHEMBL3589689)
Show SMILES Cc1c(C=C2C(=O)NC(=S)NC2=O)c2ccccc2n1Cc1ccc(Br)cc1
Show InChI InChI=1S/C15H12N2O2/c1-19-11-8-6-10(7-9-11)14-16-13-5-3-2-4-12(13)15(18)17-14/h2-9H,1H3,(H,16,17,18)
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MMDB

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Article
PubMed
n/an/an/an/a 2.50E+3n/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated NPM1 recruitment to chromatic in 6 Gy irradiated human A549 cells assessed as extraction of pT199NPM1 pretreated 30 mins...


Bioorg Med Chem 23: 3681-6 (2015)


Article DOI: 10.1016/j.bmc.2015.04.018
BindingDB Entry DOI: 10.7270/Q2H41T56
More data for this
Ligand-Target Pair