BDBM50097579 (6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine-8-carboxylic acid amide::8-CAC::8-carboxamidocyclazocine::CHEMBL58646::US9656961, Example 00157
SMILES C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)C(N)=O
InChI Key InChIKey=FAVQVALXVLMHLE-BKBNBNODSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 26 hits for monomerid = 50097579
TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Displacement of [3H]U-69593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.170nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:Binding affinity was determined towards opioid receptor mu1 using [3H]-DAMGO as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:Displacement of [3H]DAMGO from Opioid receptor mu 1 of guinea pig brain membranesMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Rochester
Curated by PDSP Ki Database
University Of Rochester
Curated by PDSP Ki Database
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Rochester
Curated by PDSP Ki Database
University Of Rochester
Curated by PDSP Ki Database
Affinity DataKi: 0.530nMAssay Description:Binding affinity was determined towards opioid receptor kappa 1 using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Rochester
Curated by PDSP Ki Database
University Of Rochester
Curated by PDSP Ki Database
Affinity DataKi: 0.530nMAssay Description:Displacement of [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brain membranesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 5.20nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 5.20nMAssay Description:Displacement of [3H]naltrindole from delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 5.20nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 8.30nMAssay Description:Displacement of [3H]naltrindole from Opioid receptor delta 1 of guinea pig brain membranesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 8.30nMAssay Description:Binding affinity was determined towards Opioid receptor delta 1 using [3H]-Naltrindole as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Antagonist activity against human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataEC50: 4.40nMAssay Description:Displacement of [3H]DAMGO from human kappa opioid receptor expressed in CHO cell membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 2.70nMAssay Description:Partial agonist activity at human mu opioid receptor expressed in CHO cell membrane assessed as stimulation of [35S]GTPgammaS binding after 60 mins b...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataEC50: 4.40nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in CHO cells assessed as inhibition of U50488-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Antagonist activity against human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Partial agonist activity at human mu opioid receptor expressed in CHO cell membrane assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding af...More data for this Ligand-Target Pair