BDBM50099062 CHEMBL3344081::US10730870, Example 3::US11512083, Example 3
SMILES CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C
InChI Key InChIKey=GFVIEZBZIUKYOG-SVFBPWRDSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50099062
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataKd: 185nMAssay Description:Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...More data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataKd: 113nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues) (unknown origin) expressed in Escherichia coli assessed as displacement of HIF-1a...More data for this Ligand-Target Pair
Affinity DataKd: 107nMAssay Description:Binding affinity to VBC (unknown origin) at 50 uM at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 123nMAssay Description:Binding affinity to VBC (unknown origin) at 50 uM at 10 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 185nMAssay Description:Binding affinity to VHL (unknown origin)/elongin C (unknown origin)/elongin B (unknown origin) by isothermal titration calorimetry-based assayMore data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Displacement of FAM-labeled HIF-1alpha peptide from VBC (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 2.54E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 696nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 1.48E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataKd: 120nMAssay Description:The surface plasmon resonance (SPR) experiments were conducted on a Biacore3000 (GE Healthcare). His-tagged VHL protein was immobilized on a carboxym...More data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 185nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.54E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Affinity DataIC50: 696nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.48E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
TargetElongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas
Curated by ChEMBL
Arvinas
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...More data for this Ligand-Target Pair