BDBM50100283 2-(3-Ethynyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile::CHEMBL22080

SMILES C#Cc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1

InChI Key InChIKey=IBIUCSOTYPMCEO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50100283   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50100283(2-(3-Ethynyl-phenoxy)-4-imidazol-1-ylmethyl-benzon...)
Affinity DataIC50:  27nMAssay Description:Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100283(2-(3-Ethynyl-phenoxy)-4-imidazol-1-ylmethyl-benzon...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed