BDBM50100296 2-(Biphenyl-3-yloxy)-4-imidazol-1-ylmethyl-benzonitrile::CHEMBL22819

SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1cccc(c1)-c1ccccc1

InChI Key InChIKey=RMXCVAFRLLKAJD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50100296   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50100296(2-(Biphenyl-3-yloxy)-4-imidazol-1-ylmethyl-benzoni...)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100296(2-(Biphenyl-3-yloxy)-4-imidazol-1-ylmethyl-benzoni...)
Affinity DataIC50:  520nMAssay Description:Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed