BDBM50100316 CHEMBL3321809

SMILES Cc1ccc(O)cc1-n1c(N)c(C(N)=O)c2nc3ccccc3nc12

InChI Key InChIKey=ZHMCGBRGDVCXLS-UHFFFAOYSA-N

Data  5 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50100316   

TargetEphrin type-A receptor 3(Human)
University of Z£Rich

Curated by ChEMBL
LigandPNGBDBM50100316(CHEMBL3321809)
Affinity DataKd:  8.60nMAssay Description:Binding affinity to EphA3 (unknown origin) by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Human)
University of Z£Rich

Curated by ChEMBL
LigandPNGBDBM50100316(CHEMBL3321809)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of phosphorylation of full-length myc-tagged human EphB4 overexpressed in mouse embryonic fibroblasts after 90 mins by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100316(CHEMBL3321809)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
LigandPNGBDBM50100316(CHEMBL3321809)
Affinity DataIC50:  68nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
TargetWee1-like protein kinase(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50100316(CHEMBL3321809)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of WEE1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50100316(CHEMBL3321809)
Affinity DataIC50:  7nMAssay Description:Inhibition of full length Nano-luc fused EPHB3 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In DepthDetails PubMed