BDBM50101913 18-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL53183

SMILES CN1c2cccc3ccc(Oc4cc(Cn5cncc5CNCC1=O)ccc4C#N)cc23

InChI Key InChIKey=MIUVLTBXZYHORO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50101913   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101913(18-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50101913(18-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50:  6.72E+3nMAssay Description:In vitro ability of the compound to displace radiolabelled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101913(18-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50:  55nMAssay Description:Inhibition of [125I]-buserelin binding to human Gonadotropin-releasing hormone receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed