BDBM50102025 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID::CHEMBL291678::[(R)-4-((E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,20-dioxo-17-(S)-oxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl)-benzyl]-phosphonic acid::[4-((10R,16S)-18-(S)-1-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,17,20-trioxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl)-benzyl]-phosphonic acid::[4-(18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,17,20-trioxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl)-benzyl]-phosphonic acid

SMILES NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)C[C@H](\C=C\C[C@@H](Cc2cccc3ccccc23)CNC1=O)c1ccc(CP(O)(O)=O)cc1

InChI Key InChIKey=RHYFMOCFCFUTNH-GZNVFMSSSA-N

Data  1 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50102025   

TargetGrowth factor receptor-bound protein 2(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50102025(4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAP...)
Affinity DataKi:  16nMAssay Description:Displacement of FITC-Ahx-PVPePYINQSVPKRK-NH2 from N-terminal His6-tagged human full length GRB2 (1 to 217 residues) expressed in Escherichia coli ass...More data for this Ligand-Target Pair
TargetGrowth factor receptor-bound protein 2(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50102025(4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAP...)
Affinity DataIC50:  26nMAssay Description:Inhibition of Growth factor receptor bound protein 2 SH2 domain in extracellular binding assayMore data for this Ligand-Target Pair
TargetGrowth factor receptor-bound protein 2(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50102025(4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAP...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to Grb2-SH2 domain (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetGrowth factor receptor-bound protein 2(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50102025(4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAP...)
Affinity DataIC50:  350nMAssay Description:Displacement of FITC-Ahx-PVPePYINQSVPKRK-NH2 from N-terminal His6-tagged human full length GRB2 (1 to 217 residues) expressed in Escherichia coli by ...More data for this Ligand-Target Pair
TargetGrowth factor receptor-bound protein 2(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50102025(4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAP...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Growth factor receptor bound protein 2 SH2 domain binding in ELISAMore data for this Ligand-Target Pair
TargetGrowth factor receptor-bound protein 2(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50102025(4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAP...)
Affinity DataIC50:  20nMAssay Description:In vitro binding affinity in extracellular ELISA-based assay for Grb2 SH2 domainMore data for this Ligand-Target Pair