BDBM50103323 4-(5-{[1-(3-Chloro-phenyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL99205

SMILES Clc1cccc(c1)N1CC[C@H](NCc2cncn2Cc2ccc(cc2)C#N)C1=O

InChI Key InChIKey=UXDWHSLPIYXEQA-NRFANRHFSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50103323   

TargetGeranylgeranyl transferase type-1 subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103323(4-(5-{[1-(3-Chloro-phenyl)-2-oxo-pyrrolidin-3-ylam...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibitory concentration of geranylgeranyl-protein transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103323(4-(5-{[1-(3-Chloro-phenyl)-2-oxo-pyrrolidin-3-ylam...)
Affinity DataIC50:  8.40nMAssay Description:In vitro inhibition of farnesyl transferase using purified recombinant human enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103323(4-(5-{[1-(3-Chloro-phenyl)-2-oxo-pyrrolidin-3-ylam...)
Affinity DataIC50:  30nMAssay Description:Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed