BDBM50103358 4-{5-[(1-Benzyl-2-oxo-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL100579

SMILES O=C1[C@@H](CCN1Cc1ccccc1)NCc1cncn1Cc1ccc(cc1)C#N

InChI Key InChIKey=MRONYHYWJWVKKK-JOCHJYFZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50103358   

TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103358(4-{5-[(1-Benzyl-2-oxo-pyrrolidin-3-ylamino)-methyl...)
Affinity DataIC50:  49nMAssay Description:In vitro inhibition of farnesyl transferase using purified recombinant human enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103358(4-{5-[(1-Benzyl-2-oxo-pyrrolidin-3-ylamino)-methyl...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibitory concentration of geranylgeranyl-protein transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103358(4-{5-[(1-Benzyl-2-oxo-pyrrolidin-3-ylamino)-methyl...)
Affinity DataIC50:  21nMAssay Description:Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed